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[突变过程频率动态的数学建模。I. 体细胞突变频率动态趋势的年龄特征]

[Mathematical modeling of the dynamics of frequency of the mutation process. I. Age features of SA frequency dynamics tendency].

作者信息

Volkov I K, Lysenko A S, Chebotarev A N

出版信息

Genetika. 1992 May;28(5):148-58.

PMID:1639256
Abstract

A mathematical method for modelling SA frequency dynamics tendencies, depending on age, for different fixation moments and in general for the whole interval of observation is suggested. The criteria of remainder dispersion attitude is used for choosing an optimal model. The initial hypothesis about discrepancies distribution law is used for checking adequateness of the optimal model to the research process. In addition, aposteriory trust intervals are built for the initial and forecast SA frequency values and the hit into them corresponding the experimental values of SA frequencies is controlled. An example of practical realization of the model proposed is considered and the results obtained analysed.

摘要

提出了一种数学方法,用于对不同固定时刻以及整个观察区间内取决于年龄的窦性心律失常(SA)频率动态趋势进行建模。使用剩余离散度态度准则来选择最优模型。关于差异分布规律的初始假设用于检验最优模型对研究过程的适用性。此外,为初始和预测的SA频率值构建后验置信区间,并控制SA频率实验值对这些区间的命中情况。考虑了所提出模型实际实现的一个示例,并对获得的结果进行了分析。

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