Thisted H, Jacobsen J, Munk E M, Nørgaard B, Friis S, McLaughlin J K, Sørensen H T, Johnsen S P
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Aliment Pharmacol Ther. 2006 Jan 1;23(1):185-90. doi: 10.1111/j.1365-2036.2006.02728.x.
Case reports have suggested that statins may cause acute pancreatitis.
To examine if statins are associated with risk of acute pancreatitis.
We identified 2576 first-time admitted cases of acute pancreatitis from hospital discharge registers in three Danish counties, and 25 817 age- and gender-matched controls from the general population. Prescriptions for statins prior to admission with acute pancreatitis or index date among controls were retrieved from prescription databases. We used conditional logistic regression analysis to estimate odds ratios for acute pancreatitis among ever (ever before), current (0-90 days before), new (first prescription in 0-90 days before) and former (>90 days, but not 0-90 days before) users of statins.
Adjusted odds ratios for acute pancreatitis among ever, current, new and former users of statins were 1.44 (95% confidence interval: 1.115-1.80), 1.26 (95% confidence interval: 0.96-1.64), 1.01 (95% confidence interval: 0.43-2.37) and 2.02 (95% confidence interval: 1.37-2.97), respectively. There was an indication of an inverse association between the number of filled prescriptions and risk of acute pancreatitis.
Our findings speak against a strong causative effect of statins on the risk of acute pancreatitis, and may even indicate a mild protective effect.
病例报告表明他汀类药物可能导致急性胰腺炎。
研究他汀类药物是否与急性胰腺炎风险相关。
我们从丹麦三个县的医院出院登记册中确定了2576例首次入院的急性胰腺炎病例，并从普通人群中选取了25817例年龄和性别匹配的对照。从处方数据库中检索急性胰腺炎入院前或对照的索引日期之前的他汀类药物处方。我们使用条件逻辑回归分析来估计他汀类药物的既往使用者（既往任何时候）、当前使用者（入院前0 - 90天）、新使用者（入院前0 - 90天内首次处方）和既往使用者（超过90天，但不是入院前0 - 90天）发生急性胰腺炎的比值比。
他汀类药物的既往使用者、当前使用者、新使用者和既往使用者发生急性胰腺炎的调整后比值比分别为1.44（95%置信区间：1.115 - 1.80）、1.26（95%置信区间：0.96 - 1.64）、1.01（95%置信区间：0.43 - 2.37）和2.02（95%置信区间：1.37 - 2.97）。有迹象表明已填充处方数量与急性胰腺炎风险之间存在负相关。
我们发现反对他汀类药物对急性胰腺炎风险有强烈因果效应，甚至可能表明有轻微保护作用。
