Kida T, Nakanuma Y, Terada T
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Hepatology. 1992 Aug;16(2):334-40. doi: 10.1002/hep.1840160209.
Cystic dilatation of peribiliary glands of intrahepatic and extrahepatic bile ducts was investigated in autopsied livers with adult polycystic disease (n = 8), in autopsied livers with solitary nonparasitic cysts (n = 18) and in normal autopsied livers (n = 23). In normal livers, cystic dilatation of intrahepatic peribiliary glands was absent or slight, when present. In livers with solitary nonparasitic cysts, cystic dilatation of intrahepatic peribiliary glands was present in varying degrees. In livers with adult polycystic disease, intrahepatic peribiliary glands showed frequent and severe cystic dilatation so marked that it was grossly recognizable. In contrast, peribiliary glands of the extrahepatic bile ducts showed no cystic dilatation in most cases, regardless of the three conditions examined. Liver parenchymal cysts were numerous in livers with adult polycystic disease, few in livers with solitary nonparasitic cysts and nonexistent in normal livers. Von Meyenburg complexes were present in 87.5% of livers with adult polycystic disease, in 16.7% of livers with solitary nonparasitic cysts and in 4.3% of normal livers. These findings suggest that intrahepatic peribiliary glands undergo cystic dilatation in livers with adult polycystic disease-and, to a lesser degree and frequency in livers with solitary nonparasitic cysts, probably because of congenital or genetic factors-and that these cystic changes may comprise a part of numerous cysts of adult polycystic disease.
对患有成人多囊肾病的尸检肝脏（n = 8）、患有孤立性非寄生虫性囊肿的尸检肝脏（n = 18）和正常尸检肝脏（n = 23）中的肝内和肝外胆管周围腺体的囊性扩张进行了研究。在正常肝脏中，肝内胆管周围腺体的囊性扩张不存在或轻微，若存在则程度较轻。在患有孤立性非寄生虫性囊肿的肝脏中，肝内胆管周围腺体存在不同程度的囊性扩张。在患有成人多囊肾病的肝脏中，肝内胆管周围腺体频繁且严重地出现囊性扩张，以至于在大体上即可识别。相比之下，无论所检查的三种情况如何，肝外胆管的胆管周围腺体在大多数情况下均未出现囊性扩张。成人多囊肾病肝脏中的肝实质囊肿数量众多，孤立性非寄生虫性囊肿肝脏中的肝实质囊肿数量较少，而正常肝脏中不存在肝实质囊肿。冯·迈恩伯格复合体在87.5%的成人多囊肾病肝脏、16.7%的孤立性非寄生虫性囊肿肝脏和4.3%的正常肝脏中存在。这些发现表明，成人多囊肾病肝脏中的肝内胆管周围腺体发生囊性扩张，在孤立性非寄生虫性囊肿肝脏中程度和频率较低，这可能是由于先天性或遗传因素所致，并且这些囊性变化可能构成成人多囊肾病众多囊肿的一部分。
