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用吗啉胍治疗流行性角膜结膜炎。临床及实验室研究(作者译)

[Treatment of epidemic keratoconjunctivitis with ABOB. Clinical and laboratory investigations (author's transl)].

作者信息

Wassileva P I, Galabov A S

出版信息

Klin Monbl Augenheilkd. 1975 Jan;166(1):77-83.

PMID:163938
Abstract

In an epidemic of viral keratoconjunctivitis in Bulgaria in 1972, caused by adenovirus 9, we applied ABOB in 1 percent solution topically in 120 of all 151 observed patients. When the treatment could be begun in first 3-5 days of the disease, a very favourable curing effect was noted. In most of the patients occurred a significant subjective improvement. The effect was most pronounced upon the course of ther keratitis stage. When ABOB was applied early, the observed keratitis was lighter, with slight visual impairment (with a duration of more than one month in 14.4 percent of the patients, as opposed to 57.3 percent in a placebo group), with quicker epithelialization of corneal erosions and, as a result, with fewer residual corneal opacities.

摘要

1972年在保加利亚发生了由腺病毒9引起的病毒性角膜结膜炎流行,在全部151例观察患者中的120例中,我们局部应用了1%溶液的吗啉胍。当在疾病的头3至5天开始治疗时,观察到非常良好的治愈效果。大多数患者出现了明显的主观改善。这种效果在角膜炎阶段的病程中最为明显。当早期应用吗啉胍时,观察到的角膜炎较轻,视力损害轻微(14.4%的患者持续时间超过一个月,而安慰剂组为57.3%),角膜糜烂上皮化更快,结果角膜残留混浊更少。

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