Nigam P K, Srivastava P, Patra P K
Department of Dermatology, Pt. J.N.M. Medical College, Raipur--492 001, India.
Indian J Dermatol Venereol Leprol. 2005 Jan-Feb;71(1):20-2. doi: 10.4103/0378-6323.13780.
Altered serum adenosine deaminase (ADA) levels have been recorded in various diseases involving lymphocytes and/or lymphoreticular system including leprosy. The study was planned to evaluate alterations in serum ADA levels, if any, in reactional and non-reactional leprosy.
Eighty patients of leprosy, comprising 60 patients of non-reactional leprosy and 20 patients of reactional leprosy were studied along with 20 normal healthy controls. Five milliliters of venous blood was collected and ADA levels were estimated by the method of Giusti (1974).
There were 54 males and 26 females. The age of the patients ranged from 5 years to 62 years. The duration of leprosy ranged from 15 days to 3 years. The mean serum ADA level in normal controls was 10.31 +/- 0.58 u/L. The serum ADA levels were raised in leprosy patients, significantly so in multibacillary patients. The serum ADA levels were higher in patients of leprosy with reaction.
The study showed significantly high serum ADA levels in multibacillary leprosy and this was further increased in patients of leprosy with reaction. This may be because of increased lymphoreticular activity during the reactional phases.
在包括麻风病在内的各种涉及淋巴细胞和/或淋巴网状系统的疾病中，血清腺苷脱氨酶（ADA）水平会发生改变。本研究旨在评估反应性和非反应性麻风病患者血清ADA水平的变化（如有）。
对80例麻风病患者进行研究，其中包括60例非反应性麻风病患者和20例反应性麻风病患者，并选取20名正常健康对照者。采集5毫升静脉血，采用朱斯蒂（1974年）的方法测定ADA水平。
患者中男性54例，女性26例。患者年龄范围为5岁至62岁。麻风病病程为15天至3年。正常对照者的平均血清ADA水平为10.31±0.58单位/升。麻风病患者的血清ADA水平升高，多菌型患者尤为显著。有反应的麻风病患者血清ADA水平更高。
该研究表明多菌型麻风病患者血清ADA水平显著升高，且有反应的麻风病患者血清ADA水平进一步升高。这可能是由于反应期淋巴网状系统活性增加所致。
