Suri Babu S S, Kannan K B, Katoch V M, Bharadwaj V P
Dept. of Biochemistry, Central JALMA Institute for Leprosy, Taj Ganj, Agra.
Indian J Lepr. 1990 Oct-Dec;62(4):473-7.
Adenosine deaminase (ADA) activity was studied in serum and peripheral blood lymphocytes of leprosy patients and healthy controls. Serum ADA levels were found to be elevated in tuberculoid as well as lepromatous cases compared to control subjects. Serum ADA activity was significantly higher in tuberculoid cases than in the lepromatous group. Lymphocyte adenosine deaminase activity showed a similar trend. These results suggest that, since the overall activity of the enzyme is not deficient in leprosy, the cellular immune abberation seen in the different types of leprosy may be due to abnormal proliferation of different subsets of lymphocytes in response to M. leprae.
对麻风病患者和健康对照者的血清及外周血淋巴细胞中的腺苷脱氨酶（ADA）活性进行了研究。与对照受试者相比，发现结核样型以及瘤型病例的血清ADA水平均升高。结核样型病例的血清ADA活性显著高于瘤型组。淋巴细胞腺苷脱氨酶活性呈现出类似趋势。这些结果表明，由于麻风病中该酶的整体活性并不缺乏，不同类型麻风病中出现的细胞免疫异常可能是由于不同亚群的淋巴细胞对麻风杆菌产生反应而异常增殖所致。
