Singhi M K, Gupta L K, Bansal Mohit, Jain Vinod, Kachhawa Dilip
Department of Dermatology, Venereology and Leprosy, Dr. S. N. Medical College, Jodhpur, India.
Indian J Dermatol Venereol Leprol. 2005 May-Jun;71(3):195-6. doi: 10.4103/0378-6323.16238.
Various paraneoplastic dermatoses may be seen in association with underlying visceral, especially gastrointestinal, malignancy. Florid cutaneous papillomatosis describes the sudden appearance of multiple acuminate keratotic papules that morphologically resemble viral warts. It may be seen in association with acanthosis nigricans and/or the sign of Leser Triotalat. We report a 35-year-old male with extensive seborrhoeic keratoses and florid cutaneous papillomatosis. Unusually marked verrucous changes caused disfigurement of the hands and feet. The patient also reported dyspepsia, abdominal distention and weight loss 6 months prior to the development of cutaneous lesions. Gastroscopy revealed a large growth in the stomach. Histopathology of the tumor showed features of adenocarcinoma.
各种副肿瘤性皮肤病可能与潜在的内脏恶性肿瘤相关,尤其是胃肠道恶性肿瘤。泛发性皮肤乳头瘤病表现为突然出现多个形态上类似病毒疣的尖状角化丘疹。它可能与黑棘皮病和/或Leser Triotalat征同时出现。我们报告一名35岁男性,患有广泛的脂溢性角化病和泛发性皮肤乳头瘤病。异常明显的疣状改变导致手足畸形。该患者还报告在皮肤病变出现前6个月有消化不良、腹胀和体重减轻。胃镜检查发现胃内有一个大的肿物。肿瘤的组织病理学显示为腺癌特征。