染色质、转录延伸与可变剪接。
Chromatin, transcript elongation and alternative splicing.
作者信息
Kornblihtt Alberto R
出版信息
Nat Struct Mol Biol. 2006 Jan;13(1):5-7. doi: 10.1038/nsmb0106-5.
PMID:16395314
Abstract
A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed.
摘要
最近的一项研究表明，染色质重塑因子SWI/SNF通过在转录延伸过程中创建内部“路障”来调节可变剪接，在这些“路障”处，RNA聚合酶II的磷酸化状态发生了质的变化。
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