Grasser Klaus D
Department of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK-9000 Aalborg, Denmark.
Trends Plant Sci. 2005 Oct;10(10):484-90. doi: 10.1016/j.tplants.2005.08.004.
Transcript elongation by RNA polymerase II (RNAPII), once regarded as the simple extension of the initiated mRNA, is a complex and highly regulated phase of the transcription cycle. Many factors have been identified that contribute to the dynamic control of the elongation stage of transcription. There are elongation factors that modulate the activity of RNAPII and other factors that facilitate the transcription through chromatin. Recent studies of mutants defective in elongation factors have revealed the importance of proper transcript elongation for the development of higher eukaryotes. Here, the essentials of transcript elongation are briefly summarized to discuss its role in developmental processes.
RNA聚合酶II（RNAPII）介导的转录延伸，曾被视为起始mRNA的简单延伸，实则是转录周期中一个复杂且受到高度调控的阶段。现已鉴定出许多有助于动态控制转录延伸阶段的因子。有些延伸因子可调节RNAPII的活性，还有些因子则促进转录通过染色质。近期对延伸因子缺陷型突变体的研究揭示了正确的转录延伸对高等真核生物发育的重要性。在此，简要总结转录延伸的要点，以探讨其在发育过程中的作用。
