von Noorden G K, Crawford M L
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.
Invest Ophthalmol Vis Sci. 1992 Aug;33(9):2729-32.
Cell shrinkage in monkey lateral geniculate nucleus (LGN) layers supplied by the amblyopic eye have been described in experimental amblyopia caused by visual deprivation, anisometropia, and strabismus. A human brain from a strabismic amblyope became available for study and the authors compared cell sizes in LGN layers receiving input from the normal and the amblyopic eye. Significant cell shrinkage was present in layers connected with the amblyopic eye, and was most evident in the ipsilateral LGN. These findings support the validity of the monkey model for the study of strabismic amblyopia by showing, for the first time, changes in the brain from a human strabismic amblyope that are similar to those previously described in monkeys.
在由视觉剥夺、屈光参差和斜视引起的实验性弱视中，已观察到弱视眼所供应的猴外侧膝状体核（LGN）层中的细胞萎缩。现获得了一名斜视性弱视患者的人脑用于研究，作者比较了接受正常眼和弱视眼输入的LGN层中的细胞大小。与弱视眼相连的层中存在明显的细胞萎缩，且在同侧LGN中最为明显。这些发现通过首次展示人类斜视性弱视患者大脑中的变化与先前在猴子中描述的变化相似，支持了猴模型用于研究斜视性弱视的有效性。
