Pollock V E, Schneider L S
Department of Psychiatry and Behavioral Sciences, University of Southern California School of Medicine, Los Angeles 90033.
Int J Psychophysiol. 1992 May;12(3):237-41. doi: 10.1016/0167-8760(92)90062-g.
The P3 event-related potential (ERP) was elicited by auditory stimuli under two conditions: (1) 250 Hz standard, 500 Hz target; and, (2) 1000 Hz standard, 2000 Hz target. A group with normal hearing (n = 10), defined as subjects with less than a 16 dB loss at each tone frequency was compared to a group with hearing impairment (n = 8), defined as subjects with a loss of 16 dB or more at each tone frequency. The hearing impaired group showed significant P3 latency prolongations compared to those with normal hearing under the 2000 Hz, but not the 500 Hz target, even though subject age was used as a covariate. Under both conditions, hearing impaired subjects showed reduced P3 amplitudes compared to those with normal hearing. These findings are discussed in relation to the sensitivity of ERP assessment procedures in older adults.
P3事件相关电位（ERP）由两种条件下的听觉刺激诱发：（1）250赫兹标准音，500赫兹目标音；以及（2）1000赫兹标准音，2000赫兹目标音。将一组听力正常者（n = 10，定义为每个音调频率损失小于16分贝的受试者）与一组听力受损者（n = 8，定义为每个音调频率损失16分贝或更多的受试者）进行比较。尽管将受试者年龄作为协变量，但与听力正常者相比，听力受损组在2000赫兹目标音而非500赫兹目标音条件下，显示出明显的P3潜伏期延长。在两种条件下，与听力正常者相比，听力受损受试者的P3波幅均降低。结合老年人ERP评估程序的敏感性对这些发现进行了讨论。
