Pollock V E, Schneider L S
Department of Psychiatry, University of Southern California School of Medicine.
Int J Neurosci. 1989 Mar;45(1-2):127-32. doi: 10.3109/00207458908986225.
The effects of tone stimulus frequency on the auditory P3 of normal younger (n = 16) and elderly (n = 23) subjects were assessed using latency and amplitude measures. Because presbycusis is prevalent among the elderly, it was hypothesized that P3s of elderly subjects elicited by a 2000 Hz target tone would show longer latencies and smaller amplitudes than those elicited by a 500 Hz target tone. As hypothesized, the results indicated that elderly subjects showed prolonged P3 latencies under a 2000 Hz, as compared to 500 Hz target tone condition, whereas younger subjects did not show such latency differences. The P3 amplitudes of the younger and elderly groups were not, however, affected by target tone frequency. The implications of these findings in clinical geriatric ERP research are discussed.
使用潜伏期和波幅测量方法，评估了纯音刺激频率对正常年轻受试者（n = 16）和老年受试者（n = 23）听觉P3的影响。由于老年人群中普遍存在老年性聋，因此推测由2000 Hz目标音诱发的老年受试者的P3潜伏期会比由500 Hz目标音诱发的P3潜伏期更长，波幅更小。正如所推测的那样，结果表明，与500 Hz目标音条件相比，老年受试者在2000 Hz条件下P3潜伏期延长，而年轻受试者未表现出这种潜伏期差异。然而，年轻组和老年组的P3波幅不受目标音频率的影响。讨论了这些发现在临床老年ERP研究中的意义。
