Vesco K K, Bone R C, Ryan J C, Polich J
Department of Psychology, University of California San Diego 92093.
Electroencephalogr Clin Neurophysiol. 1993 Jul-Aug;88(4):302-8. doi: 10.1016/0168-5597(93)90054-s.
Auditory event-related potentials (ERPs) were assessed in young and elderly subjects when stimulus intensity (40 vs. 60 dB SL) and standard/target tone frequency (250/500 Hz and 1000/2000 Hz) were manipulated to study the effects of these variables on the P3(00) and N1, P2 and N2 components. Auditory thresholds for each stimulus type were obtained, and the stimulus intensity was adjusted to effect perceptually equal intensities across conditions for each subject. Younger subjects demonstrated larger P3 amplitudes and shorter latencies than elderly subjects. The low frequency stimuli produced larger P3 amplitude and shorter latencies than the high frequency stimuli. Low intensity stimuli yielded somewhat smaller P3 amplitudes and longer peak latencies than high intensity stimulus tones. Although additional stimulus intensity and frequency effects were obtained for the N1, P2 and N2 components, these generally differed relatively little with subject age. The findings suggest that auditory stimulus parameters contribute to P3 measures, which are different for young compared to elderly subjects.
当刺激强度（40分贝感觉级与60分贝感觉级）以及标准/目标纯音频率（250/500赫兹与1000/2000赫兹）被操控时，对年轻和老年受试者的听觉事件相关电位（ERP）进行了评估，以研究这些变量对P3（00）以及N1、P2和N2成分的影响。获取了每种刺激类型的听觉阈值，并针对每个受试者在不同条件下将刺激强度调整为产生在感知上相等的强度。年轻受试者比老年受试者表现出更大的P3波幅和更短的潜伏期。低频刺激比高频刺激产生更大的P3波幅和更短的潜伏期。低强度刺激比高强度刺激音产生的P3波幅略小且峰值潜伏期更长。虽然对于N1、P2和N2成分还获得了额外的刺激强度和频率效应，但这些效应在不同年龄受试者之间通常差异相对较小。研究结果表明，听觉刺激参数对P3测量有影响，而年轻人和老年人的P3测量结果有所不同。
