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脊柱推拿可减轻大鼠腰椎椎间孔炎症后的疼痛和痛觉过敏。

Spinal manipulation reduces pain and hyperalgesia after lumbar intervertebral foramen inflammation in the rat.

作者信息

Song Xue-Jun, Gan Qiang, Cao Jun-Li, Wang Zheng-Bei, Rupert Ronald L

机构信息

Department of Neurobiology, Parker College Research Institute, Dallas, TX 75229, USA.

出版信息

J Manipulative Physiol Ther. 2006 Jan;29(1):5-13. doi: 10.1016/j.jmpt.2005.10.001.

Abstract

OBJECTIVE

To document potential mediating effects of the Activator-assisted spinal manipulative therapy (ASMT) on pain and hyperalgesia after acute intervertebral foramen (IVF) inflammation.

METHODS

The IVF inflammation was mimicked by in vivo delivery of inflammatory soup directly into the L5 IVF in adult male Sprague-Dawley rats. Thermal hyperalgesia and mechanical allodynia were determined by the shortened latency of foot withdrawal to radiant heat and von Frey filament stimulation to the hind paw, respectively. Intracellular recordings were obtained in vitro from L5 dorsal root ganglion (DRG) somata. DRG inflammation was examined by observation of the appearance and hematoxylin and eosin staining. ASMT was applied to the spinous process of L4, L5, and L6. A series of 10 adjustments were initiated 24 hours after surgery and subsequently applied daily for 7 consecutive days and every other day during the second week.

RESULTS

(1) ASMT applied on L5, L6, or L5 and L6 spinous process significantly reduced the severity and duration of thermal and mechanical hyperalgesia produced by the IVF inflammation. However, ASMT applied on L4 did not affect the response in rats with IVF inflammation or the controls; (2) electrophysiological studies showed that hyperexcitability of the DRG neurons produced by IVF inflammation was significantly reduced by ASMT; (3) pathological studies showed that manifestations of the DRG inflammation, such as the increased vascularization and satellitosis, were significantly reduced 2 to 3 weeks after ASMT.

CONCLUSIONS

These studies show that ASMT can significantly reduce the severity and shorten the duration of pain and hyperalgesia caused by lumbar IVF inflammation. This effect may result from ASMT-induced faster elimination of the inflammation and recovery of excitability of the inflamed DRG neurons by improving blood and nutrition supplement to the DRG within the affected IVF. Manipulation of a specific spinal segment may play an important role in optimizing recovery from lesions involving IVF inflammation.

摘要

目的

记录激活器辅助脊柱推拿疗法(ASMT)对急性椎间孔(IVF)炎症后疼痛和痛觉过敏的潜在中介作用。

方法

通过将炎性汤直接注入成年雄性Sprague-Dawley大鼠的L5椎间孔在体内模拟IVF炎症。分别通过缩短后爪对辐射热的缩足潜伏期和对von Frey细丝刺激的缩足潜伏期来测定热痛觉过敏和机械性异常性疼痛。在体外从L5背根神经节(DRG)神经元胞体进行细胞内记录。通过观察外观以及苏木精和伊红染色来检查DRG炎症。对L4、L5和L6棘突施加ASMT。术后24小时开始进行一系列10次调整,随后每天进行,连续7天,第二周隔天进行。

结果

(1)对L5、L6或L5和L6棘突施加ASMT可显著降低IVF炎症产生的热痛觉过敏和机械性痛觉过敏的严重程度及持续时间。然而,对L4施加ASMT对IVF炎症大鼠或对照组的反应没有影响;(2)电生理研究表明,ASMT可显著降低IVF炎症引起的DRG神经元的兴奋性;(3)病理研究表明,ASMT后2至3周,DRG炎症的表现,如血管增生和卫星现象显著减轻。

结论

这些研究表明,ASMT可显著降低腰椎IVF炎症引起的疼痛和痛觉过敏的严重程度并缩短其持续时间。这种作用可能是由于ASMT通过改善受影响椎间孔内DRG的血液供应和营养补充,从而更快地消除炎症并恢复炎症DRG神经元的兴奋性。对特定脊柱节段的推拿可能在优化涉及IVF炎症的损伤恢复中起重要作用。

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