Hu Min, Wang Junhui, Peng Qunsheng
State Key Laboratory of CAD & CG, Zhejiang University, Hangzhou, 310058, China.
Bioinformatics. 2007 Dec 15;23(24):3400-2. doi: 10.1093/bioinformatics/btm476. Epub 2007 Oct 5.
Cage-shaped protein, with its special structure, may have potential applications in biomedicine and nanotechnology. We developed a program CSPro (Cage-Shaped Protein) for efficient identification of cage-shaped proteins based on quaternary structure. CSPro is capable of revealing the corresponding cage-shaped feature more clearly and quickly than traditional visualization tools. Using CSPro, we have searched the full set of PDB (protein data bank) and three types of proteins are retrieved with notably large central cavities inside. CSPro can be used to validate if the quaternary structure of a protein is cage shaped in molecular simulation.
笼状蛋白质因其特殊结构，可能在生物医学和纳米技术中有潜在应用。我们开发了一个程序CSPro（笼状蛋白质），用于基于四级结构高效识别笼状蛋白质。与传统可视化工具相比，CSPro能够更清晰、快速地揭示相应的笼状特征。使用CSPro，我们搜索了完整的蛋白质数据库（PDB），并检索到三种内部有明显大中心腔的蛋白质。CSPro可用于在分子模拟中验证蛋白质的四级结构是否为笼状。
