Cornick J L, Hartsfield S M
Department of Small Animal Medicine and Surgery, Texas Veterinary Medical Center, College of Veterinary Medicine, Texas A&M University, College Station 77843.
J Am Vet Med Assoc. 1992 Jun 15;200(12):1952-6.
Cardiopulmonary and behavioral effects of the following tranquilizer-opioid drug combinations were compared in conscious dogs: acepromazine (0.22 mg/kg of body weight, IV) and butorphanol (0.22 mg/kg, IV); acepromazine (0.22 mg/kg, IM) and butorphanol (0.22 mg/kg, IM); and acepromazine (0.22 mg/kg, IV) and oxymorphone (0.22 mg/kg, IV). Marked sedation and lateral recumbency that required minimal or no restraint was achieved with every drug combination. Analgesia was significantly better in dogs receiving oxymorphone than in dogs receiving butorphanol, as evaluated by response to toe pinch. There were no significant differences between the effects of the 3 drug combinations on heart rate, respiratory rate, arterial blood pressure, body temperature, and arterial pH, PCO2, PO2, and bicarbonate concentration. Heart rate, respiratory rate, and systolic arterial pressure decreased significantly over time with all drug combinations. Total recovery time (minutes from the initial injection to standing) was significantly longer in the dogs given acepromazine and oxymorphone.
在清醒犬中比较了以下镇静剂 - 阿片类药物组合的心肺和行为效应：乙酰丙嗪（0.22毫克/千克体重，静脉注射）和布托啡诺（0.22毫克/千克，静脉注射）；乙酰丙嗪（0.22毫克/千克，肌肉注射）和布托啡诺（0.22毫克/千克，肌肉注射）；以及乙酰丙嗪（0.22毫克/千克，静脉注射）和羟吗啡酮（0.22毫克/千克，静脉注射）。每种药物组合均能产生明显的镇静作用和侧卧姿势，所需的约束极少或无需约束。通过对趾捏的反应评估，接受羟吗啡酮的犬的镇痛效果明显优于接受布托啡诺的犬。三种药物组合对心率、呼吸频率、动脉血压、体温以及动脉血pH、PCO2、PO2和碳酸氢盐浓度的影响无显著差异。所有药物组合使用后，心率、呼吸频率和收缩压随时间显著下降。给予乙酰丙嗪和羟吗啡酮的犬的总恢复时间（从初次注射到站立的分钟数）明显更长。
