Bach Ronald R
Minneapolis Veterans Affairs Medical Center, Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):456-61. doi: 10.1161/01.ATV.0000202656.53964.04. Epub 2006 Jan 5.
Tissue factor (TF) encryption is the post-translational suppression of TF procoagulant activity (PCA) on the cell surface. There is emerging evidence of encrypted TF in normal blood associated with monocytes and platelets. Expression of this latent TF PCA during the propagation phase of blood coagulation may contribute to hemostasis. One pathway leading to the decryption of TF PCA begins with an increase in cytosolic calcium. A large calcium influx triggers both the exposure of phosphatidylserine and the expression of TF PCA on cell surfaces. The connections between these events are reviewed along with evidence that lipid raft association may also contribute to TF encryption. The last step in the decryption of TF PCA is the proteolytic activation of zymogen factor VII. This event may be a key to understanding the different roles of intravascular and extravascular TF in the process of blood coagulation.
组织因子（TF）加密是细胞表面TF促凝活性（PCA）的翻译后抑制。越来越多的证据表明，正常血液中与单核细胞和血小板相关的TF处于加密状态。在凝血传播阶段这种潜在的TF PCA的表达可能有助于止血。导致TF PCA解密的一条途径始于胞质钙的增加。大量钙内流会触发磷脂酰丝氨酸的暴露以及细胞表面TF PCA的表达。本文综述了这些事件之间的联系以及脂质筏关联也可能有助于TF加密的证据。TF PCA解密的最后一步是酶原因子VII的蛋白水解激活。这一事件可能是理解血管内和血管外TF在凝血过程中不同作用的关键。
