• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Induction of HIF-1alpha and iNOS with siRNA: a novel mechanism for myocardial protection.

作者信息

Lefer David J

出版信息

Circ Res. 2006 Jan 6;98(1):10-1. doi: 10.1161/01.RES.0000200398.52220.cc.

DOI:10.1161/01.RES.0000200398.52220.cc
PMID:16397152
Abstract
摘要

相似文献

1
Induction of HIF-1alpha and iNOS with siRNA: a novel mechanism for myocardial protection.
Circ Res. 2006 Jan 6;98(1):10-1. doi: 10.1161/01.RES.0000200398.52220.cc.
2
Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury.脯氨酰4-羟化酶-2基因沉默激活缺氧诱导因子-1可减轻心肌缺血再灌注损伤。
Circ Res. 2006 Jan 6;98(1):133-40. doi: 10.1161/01.RES.0000197816.63513.27. Epub 2005 Nov 23.
3
[Inhibitory effect of siRNA targeting HIF-1alpha on differentiation of peripheral blood endothelial progenitor cells].[靶向缺氧诱导因子-1α的小干扰RNA对人外周血内皮祖细胞分化的抑制作用]
Ai Zheng. 2005 Nov;24(11):1293-300.
4
Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1alpha.缺氧诱导的小胶质细胞中诱导型一氧化氮合酶(iNOS)表达受PI3激酶/Akt/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路以及缺氧诱导因子-1α激活的调控。
Biochem Pharmacol. 2006 Oct 16;72(8):992-1000. doi: 10.1016/j.bcp.2006.06.038. Epub 2006 Aug 17.
5
Cortical spreading depression induces the expression of iNOS, HIF-1alpha, and LDH-A.皮层扩散性抑制可诱导诱导型一氧化氮合酶、低氧诱导因子-1α和乳酸脱氢酶A的表达。
Neuroscience. 2008 Apr 22;153(1):182-8. doi: 10.1016/j.neuroscience.2008.01.037. Epub 2008 Feb 6.
6
Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF.通过靶向缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)的小干扰RNA基因转移抑制视网膜新生血管形成
J Cell Physiol. 2009 Jan;218(1):66-74. doi: 10.1002/jcp.21566.
7
[Over-expression of hypoxia-inducible factor 1 alpha increases angiogenesis of LNCaP cells in vivo].缺氧诱导因子1α的过表达增加LNCaP细胞在体内的血管生成
Zhonghua Nan Ke Xue. 2008 May;14(5):439-44.
8
Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model.静脉注射针对缺氧诱导因子的小干扰RNA可延长Lewis肺癌模型的生存期。
Cancer Gene Ther. 2009 Mar;16(3):195-205. doi: 10.1038/cgt.2008.71. Epub 2008 Sep 26.
9
Expression of HIF-1alpha and iNOS in astrocytic gliomas: a clinicopathological study.
In Vivo. 2006 May-Jun;20(3):421-5.
10
Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells.黄芩素通过抑制BV2小鼠小胶质细胞中的活性氧和PI 3-激酶/蛋白激酶B信号通路,抑制缺氧诱导的缺氧诱导因子-1α蛋白积累和激活。
Neurosci Lett. 2008 Oct 31;444(3):264-9. doi: 10.1016/j.neulet.2008.08.057. Epub 2008 Aug 27.

引用本文的文献

1
Injured Cardiac Tissue-Targeted Delivery of TGFβ1 siRNA by FAP Aptamer-Functionalized Extracellular Vesicles Promotes Cardiac Repair.通过FAP适配体功能化细胞外囊泡实现对损伤心脏组织的靶向递送TGFβ1 siRNA可促进心脏修复。
Int J Nanomedicine. 2025 Mar 1;20:2575-2592. doi: 10.2147/IJN.S497428. eCollection 2025.
2
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets.心血管系统缺氧诱导信号:发病机制和治疗靶点。
Signal Transduct Target Ther. 2023 Nov 20;8(1):431. doi: 10.1038/s41392-023-01652-9.
3
Intermittent Hypoxic Exposure Reduces Endothelial Dysfunction.
间歇性低氧暴露可减轻血管内皮功能障碍。
Biomed Res Int. 2020 Aug 19;2020:6479630. doi: 10.1155/2020/6479630. eCollection 2020.
4
Changes in gene expression patterns in postmortem human myocardial infarction.人死后心肌梗死基因表达模式的变化。
Int J Legal Med. 2020 Sep;134(5):1753-1763. doi: 10.1007/s00414-020-02311-2. Epub 2020 May 12.
5
Cardioprotection by intermittent hypoxia conditioning: evidence, mechanisms, and therapeutic potential.间歇性低氧预处理的心脏保护作用:证据、机制和治疗潜力。
Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H216-H232. doi: 10.1152/ajpheart.00060.2018. Epub 2018 Apr 13.
6
Hypoxia inducible factor-1 improves the negative functional effects of natriuretic peptide and nitric oxide signaling in hypertrophic cardiac myocytes.缺氧诱导因子-1 改善了利钠肽和一氧化氮信号在肥厚心肌细胞中的负性功能效应。
Life Sci. 2010 Jul 3;87(1-2):9-16. doi: 10.1016/j.lfs.2010.05.002. Epub 2010 May 12.
7
Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice.iNOS、胱硫醚β合酶(CBS)基因敲除小鼠以及iNOS/CBS双基因敲除小鼠中的硝基酪氨酸化、重塑和内皮-心肌解偶联
J Cell Biochem. 2009 Jan 1;106(1):119-26. doi: 10.1002/jcb.21982.