Clevers Hans, Batlle Eduard
Hubrecht Laboratory and Centre for Biomedical Genetics, Utrecht, The Netherlands.
Cancer Res. 2006 Jan 1;66(1):2-5. doi: 10.1158/0008-5472.CAN-05-3849.
Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer.
Eph受体及其ephrin配体在胚胎发育过程中介导细胞排斥。在肠上皮中，EphB受体是Wnt信号通路的靶基因，可控制沿隐窝轴的细胞分隔。最近的研究结果表明，该受体家族在结直肠癌进展过程中起着关键作用。在这里，我们综述了肠上皮中EphB/ephrinB系统的现有知识，并讨论了它们在结直肠癌多步骤进展过程中的肿瘤抑制作用。
