Elkind-Hirsch K E, Stoner W R, Stach B A, Jerger J F
Department of Otorhinolaryngology, Methodist Hospital, Baylor College of Medicine, Houston, TX 77030.
Hear Res. 1992 Jul;60(2):143-8. doi: 10.1016/0378-5955(92)90016-g.
We evaluated the impact of the menstrual cycle on auditory brainstem response (ABR) latency in nine normally cycling women. Subjects (age 23-40 years) using no hormonal therapy were recruited and underwent ABR testing during four different phases of the same menstrual cycle: early follicular (cycle days 1 to 3); mid-cycle (cycle days 12 to 15); mid-luteal (cycle days 17 to 22), and premenstrual (cycle days 25-27). Cycles were verified by basal body temperature, and serum estrogen (E2), progesterone (P), and gonadotropin levels. A control group of nine women (age 23-40 years) on oral contraceptives (Nordette-28) was also studied four times during a pill cycle. Results show a significant increase in the latency of wave III and wave V peak latencies and in the I-V interpeak interval associated with a high estrogen state at the mid-cycle phase. No statistically significant variations in latency were found in the birth control pill group. These data suggest the existence of brainstem auditory neural pathways that are sensitive to fluctuations in E2 levels during the menstrual cycle.
我们评估了月经周期对9名月经周期正常女性的听性脑干反应（ABR）潜伏期的影响。招募了未接受激素治疗的受试者（年龄23 - 40岁），并在同一个月经周期的四个不同阶段进行ABR测试：卵泡早期（月经周期第1至3天）；周期中期（月经周期第12至15天）；黄体中期（月经周期第17至22天）和经前期（月经周期第25 - 27天）。通过基础体温以及血清雌激素（E2）、孕酮（P）和促性腺激素水平来确认月经周期。还对一组9名服用口服避孕药（诺德泰 - 28）的女性（年龄23 - 40岁）在一个服药周期内进行了4次研究。结果显示，在周期中期与高雌激素状态相关的III波和V波峰潜伏期以及I - V峰间期显著增加。避孕药组的潜伏期未发现有统计学意义的变化。这些数据表明在月经周期中存在对E2水平波动敏感的脑干听觉神经通路。
