Minamisawa Susumu, Ikeda Yasuhiro
Department of Physiology, Yokohama City University Graduate School of Medicine.
Clin Calcium. 2006 Jan;16(1):37-44.
Periodic changes in calcium (Ca(2+)) concentration in cardiomyocytes are essential for cardiac contraction and relaxation, and the intracellular Ca(2+)concentration is integrally regulated by proteins associated with the sarcoplasmic reticulum (SR), an extensive intracellular membrane system. The activity of the cardiac ryanodine receptor (RyR2) and the sarco/endoplasmic reticulum Ca(2+) ATPase 2a (SERCA2a) are known to be under fine-tuning by their intrinsic regulatory domains and associated SR proteins. A growing body of evidence, including studies using genetically engineered mouse models, has shown that Ca(2+)cycling and Ca(2+)-dependent signaling pathways play a pivotal role in heart failure. The improvement of the SR function has ameliorated effects on cardiac pump function and it has potential therapeutic value for heart failure.
心肌细胞中钙（Ca(2+)）浓度的周期性变化对于心脏的收缩和舒张至关重要，细胞内Ca(2+)浓度由与肌浆网（SR）相关的蛋白质整体调节，肌浆网是一种广泛的细胞内膜系统。已知心脏雷诺丁受体（RyR2）和肌浆/内质网Ca(2+)ATP酶2a（SERCA2a）的活性受到其内在调节结构域和相关SR蛋白的微调。越来越多的证据，包括使用基因工程小鼠模型的研究表明，Ca(2+)循环和Ca(2+)依赖性信号通路在心力衰竭中起关键作用。改善SR功能对心脏泵功能有改善作用，对心力衰竭具有潜在的治疗价值。
