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Presence of a repressor protein for testis-specific H2B (TH2B) histone gene in early stages of spermatogenesis.

作者信息

Lim K, Chae C B

机构信息

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill 27599-7260.

出版信息

J Biol Chem. 1992 Aug 5;267(22):15271-3.

PMID:1639772
Abstract

The rat testis-specific TH2B histone gene assumes a hypomethylated chromatin structure at all stages of spermatogenesis. However, the TH2B mRNA level is very low in pre-meiotic spermatogenic cells and rises sharply in meiotic pachytene spermatocytes. The low level of TH2B mRNA in pre-meiotic spermatogenic cells appears to be a result of transcriptional repression of the gene by a pre-meiotic cell-specific protein which binds to a site between the TATA element and the transcription initiation site of TH2B gene.

摘要

相似文献

1
Presence of a repressor protein for testis-specific H2B (TH2B) histone gene in early stages of spermatogenesis.
J Biol Chem. 1992 Aug 5;267(22):15271-3.
2
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S-phase-specific transcription regulatory elements are present in a replication-independent testis-specific H2B histone gene.S期特异性转录调控元件存在于一个不依赖复制的睾丸特异性H2B组蛋白基因中。
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7
Meiotic synthesis of testis histones in the rat.大鼠睾丸组蛋白的减数分裂合成
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8
Pre- and postmeiotic expression of male germ cell-specific genes throughout 2-week cocultures of rat germinal and Sertoli cells.在大鼠生精细胞与支持细胞共培养的2周时间里，雄性生殖细胞特异性基因在减数分裂前和减数分裂后的表达情况。
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Presence of a bi-directional S phase-specific transcription regulatory element in the promoter shared by testis-specific TH2A and TH2B histone genes.睾丸特异性组蛋白基因TH2A和TH2B共享的启动子中存在双向S期特异性转录调控元件。
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RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis.RFX2是一种潜在的转录调节因子，可调节组蛋白H1t以及精子发生减数分裂阶段表达的其他基因。
Biol Reprod. 2004 Nov;71(5):1551-9. doi: 10.1095/biolreprod.104.032268. Epub 2004 Jun 30.

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