Zhu Pei-yuan, Hong Ping, Huang Yu-feng
Laboratory of Immunohematology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2005 Dec;11(12):944-6.
The precursor of prostate specific antigen (proPSA) are distinct molecular forms of free PSA in serum. proPSA is comprised of native proPSA as well as several truncated forms, in which [-2] proPSA and [-4] proPSA are more prostate cancer (PCa)-associated than [-7] proPSA and [-5] proPSA. Clinical studies have recently provided evidence that [-2] proPSA can significantly improve the detection of PCa, particularly in patients with total serum PSA values less than 4 microg/L. In this paper, the mechanism and characteristics of proPSA formation and impact of proPSA on the early detection of PCa are reviewed.
前列腺特异性抗原（proPSA）的前体是血清中游离PSA的不同分子形式。proPSA由天然proPSA以及几种截短形式组成，其中[-2]proPSA和[-4]proPSA比[-7]proPSA和[-5]proPSA与前列腺癌（PCa）的相关性更强。临床研究最近提供了证据表明，[-2]proPSA可显著改善PCa的检测，尤其是在总血清PSA值小于4μg/L的患者中。本文综述了proPSA形成的机制和特点以及proPSA对PCa早期检测的影响。
