Bouyer Laurent J
Center for Interdisciplinary Research in Rehabilitation and Social Integration, Departement de Readaptation, Universite Laval, Canada G7K 1P4.
J Neurol Phys Ther. 2005 Sep;29(3):117-25. doi: 10.1097/01.npt.0000282244.31158.40.
In the late 1980s, it was clearly demonstrated that adult spinal cats can be re-trained to walk after a complete spinal cord transection, using treadmill training. This has led to profound changes in the rehabilitation of persons with spinal cord injury. The use of animal models to study training-induced locomotor plasticity after spinal cord injury has expanded since this original demonstration. The goal of the present review is to summarize findings obtained with these animal models that may be of relevance to the re-training of humans with spinal cord injury. From the complete spinal cord transection models, adaptive capacity, retention of training, task-specificity, role of cutaneous inputs, effect of training with robotic devices, and spinal cord stimulation will be discussed. From the partial spinal lesion models, the effect of ventral or dorsal lesions of the cord will be presented. Finally, the effects of drugs on training will be compared between the complete and partial spinal lesions models.
在20世纪80年代后期，有明确证据表明，成年脊髓损伤猫在脊髓完全横断后，通过跑步机训练能够重新学会行走。这给脊髓损伤患者的康复带来了深远变化。自这一最初的证明以来，利用动物模型研究脊髓损伤后训练诱导的运动可塑性的情况不断增加。本综述的目的是总结从这些动物模型中获得的、可能与脊髓损伤患者再训练相关的研究结果。对于完全脊髓横断模型，将讨论其适应能力、训练的保持、任务特异性、皮肤输入的作用、机器人设备训练的效果以及脊髓刺激。对于部分脊髓损伤模型，将介绍脊髓腹侧或背侧损伤的影响。最后，将比较完全和部分脊髓损伤模型中药物对训练的影响。
