[抑癌基因PTEN蛋白与粘着斑激酶在涎腺腺样囊性癌中的表达及其意义]
[The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance].
作者信息
Zhang Bin, Sun Chang-fu
机构信息
Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China.
出版信息
Shanghai Kou Qiang Yi Xue. 2005 Dec;14(6):578-81.
PURPOSE
To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma (SACC) and its significance.
METHODS
The expression levels of FAK and PTEN in 50 cases of SACC were detected by strepravidin-peroxidase immunohistochemical technique. SPSS10.0 software was used for Chi-square test, paried Student t test and correlation analysis.
RESULTS
The expressions of FAK in salivary adenoid cystic carcinoma was 94%, and the negative expressions of PTEN was 70%.There was a significant difference between normal salivary gland and salivary adenoid cystic carcinoma (P<0.01). A significant negative relation was found between the expression intensity of FAK protein and PTEN protein(P<0.01).No correlation between the expression intensity in cribriform,tubular, and solid group was found.
CONCLUSIONS
Activation of FAK may play a strong role in the development of SACC. PTEN was abnormally expressed in SACC. No significant different expression of FAK and PTEN were found in different clinic pathological types.
目的
探讨黏着斑激酶（FAK）和第10号染色体缺失的磷酸酶及张力蛋白同源物（PTEN）在涎腺腺样囊性癌（SACC）中的表达及其意义。
方法
采用链霉抗生物素蛋白-过氧化物酶免疫组化技术检测50例SACC中FAK和PTEN的表达水平。应用SPSS10.0软件进行卡方检验、配对t检验和相关性分析。
结果
涎腺腺样囊性癌中FAK的表达率为94%，PTEN的阴性表达率为70%。正常涎腺与涎腺腺样囊性癌之间存在显著差异（P<0.01）。FAK蛋白和PTEN蛋白的表达强度之间存在显著负相关（P<0.01）。筛状型、管状型和实体型组的表达强度之间未发现相关性。
结论
FAK的激活可能在SACC的发生发展中起重要作用。PTEN在SACC中异常表达。不同临床病理类型中FAK和PTEN的表达无显著差异。
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