[M期促进因子在涎腺腺样囊性癌中的表达]
[The expression of M-phase promoting factor in salivary adenoid cystic carcinoma].
作者信息
Qi Zhong-zheng, Shang De-hao, Qu Chang-feng, Sun Chang-fu
机构信息
Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang 110002, Liaoning Province, China.
出版信息
Shanghai Kou Qiang Yi Xue. 2007 Jun;16(3):243-6.
PURPOSE
To study the expression and clinical significance of M-phase promoting factor (MPF) in salivary adenoid cystic carcinoma (SACC).
METHODS
The expression of MPF was investigated in 40 salivary adenoid cystic carcinomas and 40 normal salivary tissues by immunohistochemistry. The expression of MPF was detected in SACC-83 and SACC-LM with Western blot. Pearson's Chi-square test, paired t test and linear correlation analysis were used to analyze the data with SPSS 11.5 software package.
RESULTS
The expression of MPF was significantly higher in salivary adenoid cystic carcinoma than in normal salivary tissues(P<0.05). There was significant correlation between the level of MPF expression and pathological type(P<0.05). The expression of MPF was significantly higher in SACC-LM than in SACC-83 (P<0.05).
CONCLUSIONS
MPF highly expressed in salivary adenoid cystic carcinoma, salivary adenoid cystic carcinoma correlated with the expression of MPF and the abnormal activation of MPF was one of the factors for the proliferation of salivary adenoid cystic carcinoma. Metastasis in salivary adenoid cystic carcinoma correlated with the expression of MPF.
目的
研究促有丝分裂因子（MPF）在涎腺腺样囊性癌（SACC）中的表达及临床意义。
方法
采用免疫组织化学法检测40例涎腺腺样囊性癌组织和40例正常涎腺组织中MPF的表达。采用蛋白质免疫印迹法检测SACC-83和SACC-LM中MPF的表达。应用SPSS 11.5软件包对数据进行Pearson卡方检验、配对t检验和线性相关分析。
结果
涎腺腺样囊性癌中MPF的表达明显高于正常涎腺组织（P<0.05）。MPF表达水平与病理类型之间存在显著相关性（P<0.05）。SACC-LM中MPF的表达明显高于SACC-83（P<0.05）。
结论
MPF在涎腺腺样囊性癌中高表达，涎腺腺样囊性癌与MPF的表达相关，MPF的异常激活是涎腺腺样囊性癌增殖的因素之一。涎腺腺样囊性癌的转移与MPF的表达相关。
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