Stanojević Marija, Krusić Melina Kalagasidis, Filipović Jovanka, Parojcić Jelena, Stupar Mirjana
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro.
Drug Deliv. 2006 Jan-Feb;13(1):1-7. doi: 10.1080/10717540500313034.
The hydrogels prepared by free radical copolymerization of acrylamide and itaconic acid were investigated with regard to their composition and crosslinking degree to find materials with satisfactory swelling and drug release properties. Samples were characterized by measuring the swelling behavior and in vitro release of paracetamol as a model drug in aqueous media with different pH values. The two-factor, three-level experimental design and response surface methodology were applied to statistically evaluate the influence of investigated factors.
对通过丙烯酰胺和衣康酸自由基共聚制备的水凝胶，研究了其组成和交联度，以寻找具有令人满意的溶胀和药物释放性能的材料。通过测量水凝胶在不同pH值的水性介质中作为模型药物的对乙酰氨基酚的溶胀行为和体外释放来表征样品。应用二因素三水平实验设计和响应面方法对所研究因素的影响进行统计评估。
