Mustonen J, Uusitupa M, Länsimies E, Vainio P, Laakso M, Pyörälä K
Department of Medicine, Kuopio University Hospital, Finland.
J Intern Med. 1992 Jul;232(1):65-72. doi: 10.1111/j.1365-2796.1992.tb00551.x.
Autonomic nervous function was evaluated in 36 patients with insulin-dependent diabetes mellitus (IDDM), 39 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 48 control subjects, all without clinically evident cardiovascular disease. Valsalva ratio and heart rate variation during deep breathing were lower in both diabetic groups than in the control group. Autonomic nervous function score (ANFS) was more abnormal in patients with IDDM than in control subjects, but was not significantly increased in patients with NIDDM. There was a negative correlation between ANFS and left ventricular diastolic filling evaluated by echocardiography or peak heart rate during exercise in both diabetic groups. There were no correlations between ANFS and left ventricular systolic function at rest or during exercise in any of the groups. In conclusion, autonomic nervous function was abnormal in middle-aged diabetic patients, and it was associated with impaired left ventricular diastolic filling at rest and decreased heart rate response to exercise, but not with left ventricular systolic function.
对36例胰岛素依赖型糖尿病（IDDM）患者、39例非胰岛素依赖型糖尿病（NIDDM）患者和48名对照者进行自主神经功能评估，所有患者均无临床明显的心血管疾病。两个糖尿病组的瓦尔萨尔瓦比率和深呼吸时的心率变异性均低于对照组。IDDM患者的自主神经功能评分（ANFS）比对照者更异常，但NIDDM患者的自主神经功能评分没有显著增加。在两个糖尿病组中，ANFS与通过超声心动图评估的左心室舒张期充盈或运动时的最高心率之间存在负相关。在任何一组中，ANFS与静息或运动时的左心室收缩功能均无相关性。总之，中年糖尿病患者的自主神经功能异常，且与静息时左心室舒张期充盈受损及运动时心率反应降低有关，但与左心室收缩功能无关。
