Mustonen J N, Uusitupa M I, Tahvanainen K, Talwar S, Laakso M, Länsimies E, Kuikka J T, Pyörälä K
Department of Medicine, Kuopio University Central Hospital, Finland.
Am J Cardiol. 1988 Dec 1;62(17):1273-9. doi: 10.1016/0002-9149(88)90273-1.
Equilibrium radionuclide angiocardiography was performed on 19 men and 17 women with insulin-dependent diabetes mellitus (IDDM) and on 24 men and 15 women with noninsulin-dependent diabetes mellitus (NIDDM) and on 24 male and 24 female control subjects aged 46 to 67 years. All were without clinically evident cardiovascular disease. No significant differences were found in left ventricular (LV) ejection fraction at rest between men with IDDM (56 +/- 1%; mean +/- standard error of the mean) or NIDDM (58 +/- 1%) and control men (58 +/- 1%), whereas LV ejection fraction was higher in women with IDDM (63 +/- 1%; p less than 0.01) and NIDDM (64 +/- 2%; p less than 0.01) than in control women (58 +/- 1%). An abnormal LV ejection fraction response to dynamic exercise (an increase of less than 5% units or a decrease) was observed in 1 control man (4%), in 8 men with IDDM (42%, p less than 0.01) and in 10 men with NIDDM (42%, p less than 0.01). The respective figures were 4 (17%) for control women, 7 (44%, difference not significant) for women with IDDM and 10 (71%, p less than 0.01) for women with NIDDM. Abnormal LV ejection fraction response to exercise in diabetic patients was not related to the metabolic control of diabetes, presence of microangiopathy or abnormalities in the autonomic nervous function. Myocardial perfusion scintigraphy performed in 18 diabetic patients in whom LV ejection fraction decreased during exercise showed a reversible perfusion defect in only 5 (28%).(ABSTRACT TRUNCATED AT 250 WORDS)
对19名男性和17名女性胰岛素依赖型糖尿病（IDDM）患者、24名男性和15名女性非胰岛素依赖型糖尿病（NIDDM）患者以及24名年龄在46至67岁的男性和24名女性对照者进行了平衡放射性核素心血管造影。所有患者均无临床明显的心血管疾病。IDDM男性（56±1%；平均值±平均标准误差）或NIDDM男性（58±1%）与对照男性（58±1%）静息时左心室（LV）射血分数无显著差异，而IDDM女性（63±1%；p<0.01）和NIDDM女性（64±2%；p<0.01）的LV射血分数高于对照女性（58±1%）。1名对照男性（4%）、8名IDDM男性（42%，p<0.01）和10名NIDDM男性（42%，p<0.01）观察到LV射血分数对动态运动的异常反应（增加小于5个百分点或降低）。对照女性、IDDM女性和NIDDM女性的相应数字分别为4（17%）、7（44%，差异不显著）和10（71%，p<0.01）。糖尿病患者运动时LV射血分数的异常反应与糖尿病的代谢控制、微血管病变的存在或自主神经功能异常无关。在18名运动时LV射血分数降低的糖尿病患者中进行的心肌灌注闪烁显像仅显示5例（28%）有可逆性灌注缺损。（摘要截断于250字）
