1-磷酸鞘氨醇和鞘氨醇磷酸胆碱：同类之物？
Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?
作者信息
Alewijnse Astrid E, Michel Martin C
机构信息
Department of Pharmacology and Pharmacotherapy, Academisch Medisch Centrum, Meibergdreef 15, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
出版信息
Br J Pharmacol. 2006 Feb;147(4):347-8. doi: 10.1038/sj.bjp.0706602.
Abstract
Sphingosine-1-phosphate and sphingosylphosphorylcholine are structurally related signalling molecules. Although they share some biological effects, it is debated whether this involves the same receptors. In this issue, Mathieson and Nixon report that these two lipids activate the same transcription factor but do so via distinct signalling pathways. Against this background, we discuss some of the potential pitfalls in studies comparing the effects of the two sphingolipids.
摘要
1-磷酸鞘氨醇和鞘氨醇磷酸胆碱是结构相关的信号分子。尽管它们具有一些共同的生物学效应，但关于这是否涉及相同的受体仍存在争议。在本期中，马西森和尼克松报告称，这两种脂质激活相同的转录因子，但通过不同的信号通路实现。在此背景下，我们讨论了比较这两种鞘脂类效应的研究中一些潜在的陷阱。
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本文引用的文献
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Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors.质子感应和溶血脂质敏感的G蛋白偶联受体：一种新型多功能受体。
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