印度钦奈女性性工作者中的细菌性阴道病

Bacterial vaginosis in female sex workers in Chennai, India.

作者信息

Uma Shanmugasundaram, Balakrishnan Pachamuthu, Murugavel Kailapuri G, Srikrishnan Aylur K, Kumarasamy Nagalingeswaran, Cecelia Jebaraj A, Anand Santhanam, Mayer Kenneth H, Celentano David, Thyagarajan Sadras P, Solomon Suniti

出版信息

Sex Health. 2005;2(4):261-2. doi: 10.1071/sh05025.

DOI:10.1071/sh05025

PMID:16402677

Abstract

Bacterial vaginosis (BV) causes obstetric and gynaecological complications and non-chlamydial/non-gonococcal pelvic inflammatory disease and has been shown to be associated with the risk of acquiring HIV and herpes simplex (HSV)-2 infections. This study investigated both the prevalence of BV and its association with STDs among 582 female sex workers living in Chennai, South India. Blood, vaginal and endocervical swabs were tested for HSV-2, HIV, Treponema pallidum, BV, Chlamydia trachomatis, Neisseria gonorrhoea and Trichomonas vaginalis. The vaginal swabs collected were Gram's stained and analysed for BV by Nugent's scoring criteria. Of the women studied, 45% (95% CI, 40.6-48.7) were positive, 39.5% (95% CI, 35.5-43.5) were negative and 16% (95% CI, 12.8-18.7) were intermediate for BV. Bacterial vaginosis positivity was directly related to concurrent infection with HSV-2 (RR 1.3, AR 12, P = 0.00), T vaginalis (RR 1.5, AR 10, P = 0.01) T. pallidum (RR 2.8, AR 16, P = 0.00) and HIV (RR 4.1, AR 52, P = 0.01). Future studies are needed to focus on the risk factors for BV.

摘要

细菌性阴道病（BV）可引发妇产科并发症及非衣原体/非淋菌性盆腔炎，且已证实与感染HIV和单纯疱疹病毒2型（HSV-2）的风险相关。本研究调查了印度南部金奈582名女性性工作者中BV的患病率及其与性传播疾病（STD）的关联。对血液、阴道及宫颈拭子进行了HSV-2、HIV、梅毒螺旋体、BV、沙眼衣原体、淋病奈瑟菌及阴道毛滴虫检测。所采集的阴道拭子进行革兰氏染色，并根据 Nugent评分标准分析BV情况。在研究的女性中，45%（95%置信区间，40.6 - 48.7）为阳性，39.5%（95%置信区间，35.5 - 43.5）为阴性，16%（95%置信区间，12.8 - 18.7）为BV中间型。细菌性阴道病阳性与HSV-2（相对危险度1.3，归因危险度12，P = 0.00）、阴道毛滴虫（相对危险度1.5，归因危险度10，P = 0.01）、梅毒螺旋体（相对危险度2.8，归因危险度16，P = 0.00）及HIV（相对危险度4.1，归因危险度52，P = 0.01）的合并感染直接相关。未来研究需要聚焦于BV的危险因素。