Wheatley Paul S, Butler Anthony R, Crane Michael S, Fox Sarah, Xiao Bo, Rossi Adriano G, Megson Ian L, Morris Russell E
School of Chemistry, University of St. Andrews, Purdie Building, UK.
J Am Chem Soc. 2006 Jan 18;128(2):502-9. doi: 10.1021/ja0503579.
Transition metal-exchanged zeolite-A adsorbs and stores nitric oxide in relatively high capacity (up to 1 mmol of NO/g of zeolite). The stored NO is released on contact with an aqueous environment under biologically relevant conditions of temperature and pH. The release of the NO can be tuned by altering the chemical composition of the zeolite, by controlling the amount of water contacting the zeolite, and by blending the zeolite with different polymers. The high capacity of zeolite for NO makes it extremely attractive for use in biological and medical applications, and our experiments indicate that the NO released from Co-exchanged zeolite-A inhibits platelet aggregation and adhesion of human platelets in vitro.
过渡金属交换的A型沸石能够以相对较高的容量吸附和储存一氧化氮（高达1毫摩尔一氧化氮/克沸石）。在与生物相关的温度和pH条件下，储存的一氧化氮在与水性环境接触时会释放出来。一氧化氮的释放可以通过改变沸石的化学成分、控制与沸石接触的水量以及将沸石与不同聚合物混合来调节。沸石对一氧化氮的高吸附容量使其在生物和医学应用中极具吸引力，并且我们的实验表明，从钴交换的A型沸石释放的一氧化氮在体外可抑制人血小板的聚集和黏附。
