[维生素C抗氧化保护对人体红细胞的作用]

[Effect of vitamin C antioxidative protection on human red blood cells].

作者信息

Zan Tong, Tao Jing, Tang Rong-Cai, Liu Yan-Chun, Liu Yi, Huang Bin, Zhou Jing-Yu, Wu Min-Hui, Liu Hong-Li

机构信息

Blood Center of Jiangsu Province, Nanjing 210042, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Dec;13(6):1106-8.

PMID:16403291

Abstract

In order to investigate the effect of antioxidants on human blood, vitamin C was selected and added into plastic blood storage bags with CPD, and stored at 25 degrees C. During 6 days of storage, some indexes as ATP, SOD, MDA, K(+) concentration and superoxide radicals were detected and were compared with control group, The results showed that ATP and SOD activity in whole blood with vitamin C during 6 days of storage was higher then that in control group (P < 0.05, P < 0.01), the MDA and plasma K(+) concentrations in stored whole blood with vitamin C during 6 days of storage were lower than that in control group (P < 0.05, P < 0.01), the superoxide radical concentrations in stored whole blood with vitamin C decreased lower than that in control group (30%). The conclusion was made that vitamin C increases activities of ATP and SOD, decreases concentrations of MDA, plasma K(+) and superoxide radicals during blood preservation.

摘要

为了研究抗氧化剂对人体血液的影响，选取维生素C并将其添加到含有CPD的塑料储血袋中，于25℃储存。在储存6天期间，检测了一些指标如三磷酸腺苷（ATP）、超氧化物歧化酶（SOD）、丙二醛（MDA）、钾离子（K⁺）浓度和超氧自由基，并与对照组进行比较。结果显示，储存6天期间添加维生素C的全血中ATP和SOD活性高于对照组（P<0.05，P<0.01），储存6天期间添加维生素C的储存全血中MDA和血浆K⁺浓度低于对照组（P<0.05，P<0.01），储存6天期间添加维生素C的储存全血中超氧自由基浓度下降幅度低于对照组（30%）。得出的结论是，维生素C在血液保存过程中可提高ATP和SOD的活性，降低MDA、血浆K⁺和超氧自由基的浓度。