Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, China.
PLoS One. 2024 Apr 18;19(4):e0295986. doi: 10.1371/journal.pone.0295986. eCollection 2024.
Although the association between nonalcoholic fatty liver disease (NAFLD) and vitamin C has been well studied, the effects of dietary potassium intake on this relationship are still unclear. Thus, this study aimed to determine the effects of dietary potassium intake on the association between vitamin C and NAFLD.
We performed a cross-sectional learn about with 9443 contributors the usage of 2007-2018 NHANES data. Multiple logistic regression evaluation has been utilized to check out the affiliation of dietary vitamin C intake with NAFLD and advanced hepatic fibrosis (AHF). Subsequently, we plotted a smoothed match curve to visualize the association. Especially, the analysis of AHF was conducted among the NAFLD population. In addition, stratified evaluation used to be developed primarily based on demographic variables to verify the steadiness of the results. Effect amendment by way of dietary potassium intake used to be assessed via interplay checks between vitamin C and NAFLD in the multivariable linear regression.
In this cross-sectional study, we found that vitamin C was negatively related to NAFLD and AHF. The relationship between vitamin C and NAFLD was different in the low, middle and high potassium intake groups. Furthermore, potassium intake significantly modified the negative relationship between vitamin C and NAFLD in most of the models.
Our research showed that potassium and vitamin C have an interactive effect in reducing NAFLD, which may have great importance for clinical medication.
尽管非酒精性脂肪性肝病（NAFLD）与维生素 C 之间的关联已得到充分研究，但膳食钾摄入量对此关系的影响仍不清楚。因此，本研究旨在确定膳食钾摄入量对维生素 C 与 NAFLD 之间关联的影响。
我们使用 2007-2018 年 NHANES 数据进行了一项横断面研究，共纳入了 9443 名参与者。采用多变量逻辑回归分析评估膳食维生素 C 摄入量与 NAFLD 和晚期肝纤维化（AHF）之间的关联。随后，我们绘制了平滑匹配曲线来直观地观察关联。特别是，在 NAFLD 人群中进行了 AHF 的分析。此外，还根据人口统计学变量进行了分层评估，以验证结果的稳定性。通过维生素 C 和 NAFLD 之间的交互检验在多变量线性回归中评估了膳食钾摄入量的效果修正。
在这项横断面研究中，我们发现维生素 C 与 NAFLD 和 AHF 呈负相关。维生素 C 与 NAFLD 之间的关系在低钾、中钾和高钾摄入组中有所不同。此外，在大多数模型中，钾摄入量显著改变了维生素 C 与 NAFLD 之间的负相关关系。
我们的研究表明，钾和维生素 C 在降低 NAFLD 方面具有交互作用，这对于临床用药可能具有重要意义。
