Richelsen Bjørn, Vrang Niels
Arhus Universitetshospital, Endokrinologisk Afdeling C, Arhus Sygehus, DK-8000 Arhus C.
Ugeskr Laeger. 2006 Jan 9;168(2):159-63.
In general, treatment of obesity results in only relatively moderate weight loss (5-10%). Another major problem is long-term weight loss maintenance. The reason for the weight regain after weight loss is related to both psychological and basal physiological mechanisms. In this review we summarise the research from both animal and human studies showing that there are powerful physiological reactions that can be detected in association with weight loss. Weight loss seems to result in a pronounced stimulation of the appetite and a long-lasting fall in both the basal and exercise-induced metabolic rates. These energy-conserving mechanisms may partially explain the difficulty in maintaining weight loss.
一般来说，肥胖治疗仅能带来相对适度的体重减轻（5-10%）。另一个主要问题是长期维持体重减轻。体重减轻后体重反弹的原因与心理和基础生理机制都有关。在本综述中，我们总结了来自动物和人体研究的成果，这些研究表明，与体重减轻相关的有强大的生理反应。体重减轻似乎会导致食欲明显增强，基础代谢率和运动诱导的代谢率长期下降。这些节能机制可能部分解释了维持体重减轻的困难。
