Gruson Lisa Moed, Latkowski Jo-Ann
Department of Dermatology, New York University School of Medicine, USA.
Dermatol Online J. 2005 Dec 30;11(4):17.
A 63-year-old Chinese man presented with an eczematous dermatitis that progressed into a multifocal nodular eruption. Histopathologic examination demonstrated a nodular and diffuse infiltrate in the reticular dermis, which was composed of lymphocytes, macrophages with granulomatous inflammation, and numerous eosinophils. Reactive lymphoid follicles with germinal centers also were present. Immunohistochemistry showed CD30 and LCA. ALK-1 and CD20 were negative. A diagnosis of CD30+ cutaneous T-cell lymphoma was made, and the patient is currently undergoing staging of his disease. Treatment options include excision of nodules, radiation therapy, and systemic chemotherapy.
一名63岁的中国男性患者，最初表现为湿疹性皮炎，后进展为多灶性结节性皮疹。组织病理学检查显示，网状真皮层有结节状和弥漫性浸润，由淋巴细胞、伴有肉芽肿性炎症的巨噬细胞和大量嗜酸性粒细胞组成。同时还存在有生发中心的反应性淋巴滤泡。免疫组织化学显示CD30和LCA阳性，ALK-1和CD20阴性。诊断为CD30 + 皮肤T细胞淋巴瘤，该患者目前正在进行疾病分期。治疗方案包括结节切除、放射治疗和全身化疗。
