Crifò C, Capuozzo E, Siems W, Salerno C
Department of Biochemical Sciences and Laboratory of Clinical Biochemistry, University of Rome La Sapienza, Rome, Italy.
Biofactors. 2005;24(1-4):137-40. doi: 10.1002/biof.5520240116.
4-Hydroxy-2,3-trans-nonenal (HNE), a major lipid peroxidation product, has been shown to react with specific amino acid residues of proteins and alter their function. In vitro exposure of erythrocyte ghosts and neutrophil membranes to HNE results in the inhibition of ion transport ATPases. Neutrophil membrane Ca2+-ATPase is strongly inhibited by micromolar concentrations of HNE, while HNE is considerably less effective against neutrophil Mg2+-ATPase and the erythrocyte ghost enzymes.
4-羟基-2,3-反式壬烯醛（HNE）是一种主要的脂质过氧化产物，已被证明可与蛋白质的特定氨基酸残基发生反应并改变其功能。红细胞血影和中性粒细胞膜在体外暴露于HNE会导致离子转运ATP酶受到抑制。微摩尔浓度的HNE可强烈抑制中性粒细胞膜Ca2+-ATP酶，而HNE对中性粒细胞Mg2+-ATP酶和红细胞血影酶的作用则弱得多。
