光动力疗法对荷Lewis肺癌小鼠肿瘤血管生成和转移的影响。
Effect of photodynamic therapy on tumor angiogenesis and metastasis in mice bearing Lewis lung carcinoma.
作者信息
Lisnjak I O, Kutsenok V V, Polyschuk L Z, Gorobets O B, Gamaleia N F
机构信息
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine.
出版信息
Exp Oncol. 2005 Dec;27(4):333-5.
AIM
To investigate the influence of photodynamic therapy (PDT) on the tumor angiogenesis and metastasis.
METHODS
The effect of PDT with a photosensitizer 5-aminolaevulinic acid (ALA) on tumor metastasis and angiogenesis was studied on the model of subcutaneously implanted Lewis lung carcinoma (3LL) in C57Bl/6 mice. VEGF level in blood serum of animals was evaluated by ELISA.
RESULTS
It has been shown that application of ALA-PDT resulted in the lowered rate of metastatic spreading and decreased VEGF level in blood serum of 3LL-bearing mice, and morphologic alterations of vascular system in tumor tissue.
CONCLUSION
The antitumor action of PDT using ALA as a photosensitizer is caused partly by antimetastatic and photodamaging effect mediated by vascularization disturbances in tumor tissue.
目的
研究光动力疗法（PDT）对肿瘤血管生成和转移的影响。
方法
在C57Bl/6小鼠皮下植入Lewis肺癌（3LL）模型上，研究使用光敏剂5-氨基酮戊酸（ALA）的光动力疗法对肿瘤转移和血管生成的作用。通过酶联免疫吸附测定法评估动物血清中的血管内皮生长因子（VEGF）水平。
结果
已表明应用ALA-PDT导致荷3LL小鼠的转移扩散率降低、血清中VEGF水平下降以及肿瘤组织血管系统的形态学改变。
结论
以ALA作为光敏剂的光动力疗法的抗肿瘤作用部分是由肿瘤组织血管化紊乱介导的抗转移和光损伤作用引起的。
Zotero 插件