Bhuvaneswari Ramaswamy, Gan Yik Yuen, Soo Khee Chee, Olivo Malini
National Cancer Centre Singapore, 11 Hospital Drive, Singapore.
Cell Mol Life Sci. 2009 Jul;66(14):2275-83. doi: 10.1007/s00018-009-0016-4. Epub 2009 Mar 31.
Photodynamic therapy (PDT), the activation of a photosensitive drug in tumor tissue with light of specific wavelength, has been used effectively to treat certain solid tumors. Though therapeutic responses are encouraging, PDT-mediated oxidative stress can act as an angiogenic switch that ultimately leads to neovascularization and tumor recurrence. This article explores the effect of PDT on angiogenesis in different tumor models. Overexpression of proangiogenic vascular endothelial growth factor, cyclooxygenase-2 and matrix metalloproteases has often been reported post-illumination. Recent clinical studies have demonstrated that inhibiting angiogenesis after chemotherapy and radiotherapy is an attractive and valuable approach to cancer treatment. In this review, we report the effective therapeutic strategy of combining angiogenesis inhibitors with PDT to control and treat tumors.
光动力疗法（PDT），即通过特定波长的光激活肿瘤组织中的光敏药物，已被有效地用于治疗某些实体瘤。尽管治疗反应令人鼓舞，但PDT介导的氧化应激可作为一种血管生成开关，最终导致新血管形成和肿瘤复发。本文探讨了PDT在不同肿瘤模型中对血管生成的影响。光照后常报道促血管生成的血管内皮生长因子、环氧合酶-2和基质金属蛋白酶的过表达。最近的临床研究表明，化疗和放疗后抑制血管生成是一种有吸引力且有价值的癌症治疗方法。在本综述中，我们报告了将血管生成抑制剂与PDT联合使用以控制和治疗肿瘤的有效治疗策略。
