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儿童肝母细胞瘤的外科治疗

Surgical treatment of hepatoblastoma in children.

作者信息

Czauderna Piotr, Otte Jean-Bernard, Roebuck Derek J, von Schweinitz Dietrich, Plaschkes Jack

机构信息

Department of Paediatric Surgery, Medical University of Gdansk, ul. Nowe Ogrody 1-6, Gdansk 80-803, Poland.

出版信息

Pediatr Radiol. 2006 Mar;36(3):187-91. doi: 10.1007/s00247-005-0067-0. Epub 2006 Jan 11.

DOI:10.1007/s00247-005-0067-0
PMID:16404555
Abstract

Hepatoblastoma is the most common liver malignancy in children. With rare exceptions, complete tumour resection is required to cure the patient. Radical tumour resection can be obtained either with standard partial hepatectomy or orthotopic liver transplantation. At present, the surgical approach to hepatoblastoma differs significantly between treatment groups in different parts of the world. Our aim was to review current surgical policy in hepatoblastoma. All aspects of surgery in hepatoblastoma are discussed, including biopsy, tumour resection principles, modern achievements in the field of liver surgery, and the indications and potential contraindications for liver transplantation. Every effort should be made to resect hepatoblastoma completely either by standard partial hepatectomy or by the use of liver transplantation in difficult or clearly unresectable cases.

摘要

肝母细胞瘤是儿童最常见的肝脏恶性肿瘤。除极少数例外情况,患者治愈需要完整切除肿瘤。根治性肿瘤切除可通过标准的部分肝切除术或原位肝移植实现。目前,世界各地不同治疗组对肝母细胞瘤的手术方式差异显著。我们的目的是回顾当前肝母细胞瘤的手术策略。本文讨论了肝母细胞瘤手术的各个方面,包括活检、肿瘤切除原则、肝脏手术领域的现代成果以及肝移植的适应证和潜在禁忌证。应尽一切努力通过标准的部分肝切除术完整切除肝母细胞瘤,对于困难或明显无法切除的病例则采用肝移植。

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Surgical treatment of hepatoblastoma in children.儿童肝母细胞瘤的外科治疗
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Successful liver transplant for unresectable hepatoblastoma.不可切除性肝母细胞瘤的成功肝移植术。
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本文引用的文献

1
Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience.肝母细胞瘤的肝移植:国际小儿肿瘤学会(SIOP)研究SIOPEL-1的结果及全球经验回顾
Pediatr Blood Cancer. 2004 Jan;42(1):74-83. doi: 10.1002/pbc.10376.
2
The influence of preoperative chemotherapy and surgical technique in the treatment of hepatoblastoma--a report from the German Cooperative Liver Tumour Studies HB 89 and HB 94.术前化疗和手术技术对肝母细胞瘤治疗的影响——来自德国肝脏肿瘤协作研究HB 89和HB 94的报告
Eur J Pediatr Surg. 2002 Aug;12(4):255-61. doi: 10.1055/s-2002-34484.
3
二氢杨梅素通过调节超氧化物歧化酶1/活性氧途径在肝母细胞瘤中发挥肿瘤抑制作用。
Front Oncol. 2023 May 15;13:1160548. doi: 10.3389/fonc.2023.1160548. eCollection 2023.
4
miR-139-3p/Wnt5A Axis Inhibits Metastasis in Hepatoblastoma.miR-139-3p/Wnt5A 轴抑制肝癌转移。
Mol Biotechnol. 2023 Dec;65(12):2030-2037. doi: 10.1007/s12033-023-00714-1. Epub 2023 Mar 14.
5
Surgical management in hepatoblastoma: points to take.肝母细胞瘤的外科治疗:要点。
Pediatr Surg Int. 2023 Jan 12;39(1):81. doi: 10.1007/s00383-022-05356-z.
6
High Expression of ROMO1 Aggravates the Malignancy of Hepatoblastoma.ROMO1的高表达加剧肝母细胞瘤的恶性程度。
J Oncol. 2021 Sep 1;2021:2341719. doi: 10.1155/2021/2341719. eCollection 2021.
7
Hepatoblastoma in a Young Adult: a Rare Case Report and Review of the Literature.一名年轻成人的肝母细胞瘤:一例罕见病例报告及文献综述
J Gastrointest Cancer. 2020 Mar;51(1):319-324. doi: 10.1007/s12029-019-00256-3.
8
Metformin attenuates hypoxia-induced resistance to cisplatin in the HepG2 cell line.二甲双胍可减轻缺氧诱导的HepG2细胞系对顺铂的耐药性。
Oncol Lett. 2019 Feb;17(2):2431-2440. doi: 10.3892/ol.2018.9869. Epub 2018 Dec 24.
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Medicine (Baltimore). 2018 Oct;97(42):e12607. doi: 10.1097/MD.0000000000012607.
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Chemotherapy for suspected hepatoblastoma without efforts at surgical resection is a bad practice.
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Pediatr Radiol. 2000 Jul;30(7):481-8. doi: 10.1007/s002470000244.
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