Meerbach Astrid, Sauerbrei Andreas, Meerbach Werner, Bittrich Hans-Jörg, Wutzler Peter
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University of Jena, Hans-Knöll-Street 2, 07745 Jena, Germany.
Med Microbiol Immunol. 2006 Jun;195(2):101-5. doi: 10.1007/s00430-005-0009-3. Epub 2006 Jan 11.
In neonates, herpes simplex virus (HSV) infections can lead to severe diseases associated with high mortality. We report a 6-day-old girl who developed clinical signs of fulminant hepatic failure accompanied by infectious-toxic shock and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The diagnosis was performed postmortem by demonstration of HSV-1 DNA in liver tissue as well as by retrospective detection of HSV-specific antibodies.
在新生儿中，单纯疱疹病毒（HSV）感染可导致与高死亡率相关的严重疾病。我们报告一名6日龄女婴，她出现了暴发性肝衰竭的临床症状，伴有感染性中毒性休克和继发于1型单纯疱疹病毒（HSV-1）感染的弥散性凝血障碍。诊断是在死后通过在肝组织中检测到HSV-1 DNA以及回顾性检测HSV特异性抗体来进行的。
