Görgü Metin, Silistreli Ozlem Karataş, Karantinaci Burçe, Ayhan Meltem, Ozdemirkiran Tolga, Celebisoy Mehmet
Ataturk Training and Research Hospital, Izmir, Turkey.
Aesthetic Plast Surg. 2006 Jan-Feb;30(1):59-64. doi: 10.1007/s00266-004-0015-7.
Injection of botulinum toxin is a painful procedure, limiting the number of patients treated. This study was designed to establish whether infiltration of local anesthetics plays a role in the effectiveness of botulinum toxin. For the study, 24 New Zealand white rabbits were divided into three groups. In all three groups, local anesthetics (prilocaine, lidocaine, lidocaine, and epinephrine) were injected into the right anterior auricular muscle before a 2.5-U injection of botox A. The contralateral anterior auricular muscle of all the rabbits was injected with the same dose of the toxin to serve as a control. Photographic documentation was recorded; electromyographic study was performed; and results were statistically analyzed. The results show that local anesthetics do not play a role in the efficacy of botulinum toxin. Thus, the use of infiltrative local anesthetics before botulinum toxin injection is a safe method for achieving a less painful procedure for the patient.
注射肉毒杆菌毒素是一个痛苦的过程，限制了接受治疗的患者数量。本研究旨在确定局部麻醉剂的浸润是否在肉毒杆菌毒素的有效性中起作用。在该研究中，24只新西兰白兔被分为三组。在所有三组中，在注射2.5单位A型肉毒毒素之前，将局部麻醉剂（丙胺卡因、利多卡因、利多卡因和肾上腺素）注入右耳前肌。所有兔子的对侧耳前肌注射相同剂量的毒素作为对照。进行了摄影记录；进行了肌电图研究；并对结果进行了统计分析。结果表明，局部麻醉剂在肉毒杆菌毒素的疗效中不起作用。因此，在注射肉毒杆菌毒素之前使用浸润性局部麻醉剂是一种为患者实现疼痛较轻手术的安全方法。
