Park Si-Yeok, Park Young-Wook, Ji Young-Jun, Park Sung-Wook, Kim Seong-Gon
Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea.
Department of Biomedical Engineering, Ulsan University, Ulsan, Republic of Korea.
Maxillofac Plast Reconstr Surg. 2015 Feb 24;37(1):10. doi: 10.1186/s40902-015-0010-8. eCollection 2015 Dec.
The aim of this study was to investigate the effect of a botulinum toxin type A (BTX-A) injection in the masseter muscle using electromyography (EMG) in an animal model.
Ten male adult (>3 months of age) New Zealand white rabbits were used. Muscle activity was continuously recorded from 8 hours before to 8 hours after BTX-A injection. The rabbits received unilateral BTX-A injections of either 5 units (group 1, n = 5) or 20 units (group 2, n = 5).
The masseter muscle activity of the rabbits was significantly reduced immediately after BTX-A injection (P < 0.05 for both groups). When the results from group 1 were compared with those from group 2, only the peak voltage was significantly decreased in group 2 (P = 0.013).
Masseter muscle activity measured by EMG was immediately decreased after a BTX-A injection.
本研究旨在通过动物模型，利用肌电图（EMG）研究A型肉毒杆菌毒素（BTX-A）注射咬肌的效果。
选用10只成年雄性（>3月龄）新西兰白兔。在BTX-A注射前8小时至注射后8小时持续记录肌肉活动。兔子单侧注射5单位（第1组，n = 5）或20单位（第2组，n = 5）的BTX-A。
BTX-A注射后，兔子咬肌活动立即显著降低（两组P均<0.05）。将第1组结果与第2组比较时，仅第2组的峰值电压显著降低（P = 0.013）。
BTX-A注射后，通过EMG测量的咬肌活动立即降低。
