Lin Jen-Kun, Lin-Shiau Shoei-Yn
Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Mol Nutr Food Res. 2006 Feb;50(2):211-7. doi: 10.1002/mnfr.200500138.
Among the health-promoting effects of tea and tea polyphenols, the cancer-chemopreventive effects in various animal model systems have been intensively investigated; meanwhile, the hypolipidemic and antiobesity effects in animals and humans have also become a hot issue for molecular nutrition and food research. It has been demonstrated that the body weights of rats and their plasma triglyceride, cholesterol, and LDL-cholesterol have been significantly reduced by feedings of oolong, black, pu-erh, and green tea leaves to the animals. It has been suggested that the inhibition of growth and suppression of lipogenesis in MCF-7 breast cancer cells may be through down-regulation of fatty acid synthase gene expression in the nucleus and stimulation of cell energy expenditure in the mitochondria. The experimental data indicated that the molecular mechanisms of fatty acid synthase gene suppression by tea polyphenols (EGCG, theaflavins) may invite down-regulation of EGFR/PI3K/Akt/Sp-1 signal transduction pathways.
在茶和茶多酚的健康促进作用中，其在各种动物模型系统中的癌症化学预防作用已得到深入研究；与此同时，其在动物和人类中的降血脂和抗肥胖作用也已成为分子营养和食品研究的热点问题。已经证明，给动物喂食乌龙茶、红茶、普洱茶和绿茶叶片后，大鼠的体重及其血浆甘油三酯、胆固醇和低密度脂蛋白胆固醇显著降低。有人提出，对MCF - 7乳腺癌细胞生长的抑制和脂肪生成的抑制可能是通过下调细胞核中脂肪酸合酶基因的表达以及刺激线粒体中的细胞能量消耗来实现的。实验数据表明，茶多酚（表没食子儿茶素没食子酸酯、茶黄素）抑制脂肪酸合酶基因的分子机制可能导致表皮生长因子受体/磷脂酰肌醇-3激酶/蛋白激酶B/特异性蛋白1信号转导通路的下调。
