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影响治疗性内镜逆行胰胆管造影术困难手术结果的危险因素和技术

Risk factors and techniques affecting surgical outcome of therapeutic endoscopic retrograde cholangiopancreatography difficulties.

作者信息

Gomutbutra Theerawood

机构信息

Department of Surgery, Nakornping Hospital, Chiang Mai, Marim, Thailand.

出版信息

J Med Assoc Thai. 2005 Aug;88(8):1103-9.

Abstract

OBJECTIVE

To analyze the therapeutic endoscopic retrograde cholangiopancreatography (ERCP) difficulties and complications experienced by a general surgeon and identify risk factors and technique affecting surgical outcome.

MATERIAL AND METHOD

A retrospective review was carried out in 88 consecutive ERCP operated with four different indications on patients in Nakornping General Hospital by a surgeon trained from Nippon Medical School, Japan.

RESULTS

The patients average age was 57.2 years. Fifty-four patients had common bile duct stone and 43 of them were successfully removed. Endoscopic sphincterotomy (EST) was the most frequent procedure needed to combine with the stone extraction (23 in 43). Twenty-two distal common bile duct obstructions unable to be diagnosed by ultrasound or computed tomography were operated on and found to be unvarying proportion of tumor, stone or stricture. Among these 6 biopsy and 12 treatments were concurrently made. Eight bile fistula and four cholangitis were indicated for endoscopic drainage. Only one serious bleeding was complicated. Two perforations were discovered in the present series and none required laparotomy repair of duodenum. Eighteen of the 88 failed to be operated on and most of them were within first four-month learning curve. Duodenal diverticulum was a common failure factor. The pre-procedure unknown diagnosis relates to an insignificant risk 2.4 times complications of the known (RR = 2.4, p = 0.31). Three patients (3.4%), all over 70 years old, succumbed late after ERCP due to sepsis and myocardial infarction, compared to those age under 70 is a significant risk factor (p = 0.059). Age over 50 seems to result in a higher pancreatitis complication (3 versus none under 50) but not statistically significant (p = 0.405).

CONCLUSION

Skill and synchronous assistance are important factors for success of ERCP but a more unpredictable outcome and complications were encountered for the preoperative undiagnosable obstructive jaundice. Hot and slow sphincterotomy would minimize the bleeding complication. Duodenal diverticulum and those operated on for late obstruction were risk factors in patients with EST perforations. Pondering to be minimally by invasive, advanced age still contributes to a higher complication and mortality risk in the surgical treatment of ERCP.

摘要

目的

分析普通外科医生进行内镜逆行胰胆管造影术(ERCP)时遇到的治疗困难及并发症,确定影响手术结果的危险因素和技术。

材料与方法

对日本日本医科大学培训的一名外科医生在那空平综合医院连续为88例有四种不同适应证的患者进行ERCP手术的情况进行回顾性分析。

结果

患者平均年龄为57.2岁。54例患者患有胆总管结石,其中43例成功取出结石。内镜括约肌切开术(EST)是结石取出术最常需要联合的操作(43例中有23例)。对22例超声或计算机断层扫描无法诊断的胆总管远端梗阻进行了手术,发现肿瘤、结石或狭窄的比例不变。其中同时进行了6次活检和12次治疗。8例胆瘘和4例胆管炎需要内镜引流。仅发生1例严重出血并发症。本系列中发现2例穿孔,均无需进行十二指肠剖腹修补术。88例中有18例手术失败,其中大多数处于最初4个月的学习曲线内。十二指肠憩室是常见的失败因素。术前未明确诊断与已知诊断相比,并发症风险无显著差异(风险比=2.4,p=0.31)。3例患者(3.4%),均为70岁以上,ERCP术后因败血症和心肌梗死晚期死亡,与70岁以下患者相比,年龄是一个显著的危险因素(p=0.059)。50岁以上患者似乎胰腺炎并发症发生率较高(3例,50岁以下无),但无统计学意义(p=0.405)。

结论

技能和同步协助是ERCP成功的重要因素,但术前无法诊断的梗阻性黄疸手术结果和并发症更难以预测。热凝和缓慢括约肌切开术可将出血并发症降至最低。十二指肠憩室和晚期梗阻手术患者是EST穿孔的危险因素。考虑到微创性,高龄在ERCP手术治疗中仍会导致较高的并发症和死亡风险。

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