Shestakova I V, Iushchuk N D, Andreev I V, Shepeleva G K, Popova T I
Ter Arkh. 2005;77(11):7-10.
To evaluate clinical significance of changes in IL-6 concentration and neopterin in peripheral blood of patients for prognosis of the course and outcome of yersinia infection (YI).
Clinical examination and laboratory tests, 1-5-year follow-up were conducted in 68 patients with a cyclic, recurrent and lingering course of the disease. IL-6 and neopterin concentrations were measured in the course of the disease.
Dynamic control over IL-6 concentrations in the blood of patients with yersinia infection provides information predicting the disease course and prognosis. Blood concentrations of neopterin are of help in prognostication of long-term outcomes of acute infection.
Pathological syndromes forming in acute stage of yersinia infection are related to interleukin-dependent immunopathology.
评估耶尔森菌感染（YI）患者外周血中白细胞介素-6（IL-6）浓度和新蝶呤变化对病程及预后的临床意义。
对68例呈周期性、复发性和迁延性病程的患者进行临床检查和实验室检测，并进行1至5年的随访。在疾病过程中检测IL-6和新蝶呤浓度。
对耶尔森菌感染患者血液中IL-6浓度进行动态监测可提供预测疾病病程和预后的信息。新蝶呤的血浓度有助于预测急性感染的长期预后。
耶尔森菌感染急性期形成的病理综合征与白细胞介素依赖性免疫病理学有关。
