对在日本分离出的H5N1甲型流感病毒致病性的实验评估。
Experimental assessment of the pathogenicity of H5N1 influenza A viruses isolated in Japan.
作者信息
Mase Masaji, Imada Tadao, Nakamura Kikuyasu, Tanimura Nobuhiko, Imai Kunitoshi, Tsukamoto Kenji, Yamaguchi Shigeo
机构信息
Department of Infectious Diseases, National Institute of Animal Health, 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan.
出版信息
Avian Dis. 2005 Dec;49(4):582-4. doi: 10.1637/7364-041105R.1.
We examined the pathogenicity for chickens of two H5N1 avian influenza viruses isolated in Japan, A/chicken/ Yamaguchi/7/2004 (Ck/Yamaguchi/7/04) isolated from outbreaks in commercial layer chickens, and A/duck/Yokohama/aq10/ 2003 (Dk/Yokohama/aq10/03) isolated from duck meat imported from China. All chickens inoculated intranasally with either strain died, and the viruses were reisolated from all organs examined. However, both the mean time of onset of clinical signs and the mean death time of Ck/Yamaguchi/7/04 were shorter than those of Dk/Yokohama/aq10/03.
我们检测了在日本分离出的两种H5N1禽流感病毒对鸡的致病性，其中一种是从商品蛋鸡疫情中分离出的A/鸡/山口/7/2004（Ck/山口/7/04），另一种是从自中国进口的鸭肉中分离出的A/鸭/横滨/aq10/2003（Dk/横滨/aq10/03）。经鼻内接种任一毒株的所有鸡均死亡，且在所检查的所有器官中均重新分离到了病毒。然而，Ck/山口/7/04的临床症状平均发病时间和平均死亡时间均短于Dk/横滨/aq10/03。
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