State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Arch Virol. 2012 Jun;157(6):1131-6. doi: 10.1007/s00705-012-1259-1. Epub 2012 Feb 28.
This study describes the characterization of seven H5N1 avian influenza viruses from domestic ducks in Eastern China in 2011. Phylogenetic analysis showed these viruses were closely related to an H5N1 virus circulating in wild birds in Hong Kong. Some characteristics of these viruses were similar to those of an H5N1 strain that circulated in China and Vietnam (2003-2004). The virulence of three isolates was examined in chickens and mice, and they were found to be highly pathogenic in chickens but showed low pathogenicity in mice. These results suggest that continued H5N1 surveillance in poultry should be used as an early warning system for avian influenza outbreaks.
本研究描述了 2011 年中国东部家养鸭中分离的 7 株 H5N1 禽流感病毒的特征。系统进化分析显示这些病毒与在香港野鸟中流行的 H5N1 病毒密切相关。这些病毒的一些特性与在中国和越南流行的 H5N1 株（2003-2004 年）相似。对 3 株分离株的毒力进行了鸡和小鼠检测，结果发现它们在鸡中具有高致病性，但在小鼠中显示低致病性。这些结果表明，应继续对家禽中的 H5N1 进行监测，作为禽流感暴发的预警系统。
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