Raĭkhlin N T, Smirnova E A, Pavlovskaia A I, Rotin D L, Gurevich L E, Savelov N A
Arkh Patol. 2005 Nov-Dec;67(6):13-6.
Oncocytic adenomas have primarily follicular structure; trabeculas, solid areas, necrosis are rare. They may possess malignant potential as their malignant transformation occurs in 35% cases against 5% in adenomas of follicular cells. Oncocytic follicular carcinomas can be hardly distinguished from oncocytic adenomas. Tumors larger than 4-5 cm in diameter are considered to be malignant. Main difference with adenomas is invasion into the capsule surrounding thyroid or into the vessels. They can be well or poorly differentiated or anaplastic. Oncocytic papillary carcinoma and oncocytic medullary carcinoma are rare. The clinical course of oncocytic tumors is more aggressive than that of tumors from follicular cells. Of key importance in differential diagnosis is electron microscopy (EM) and immunohistochemistry with antimitochondrial antibodies. EM may be also useful in determination of the degree of oncocytic tumors maturation.
嗜酸性细胞瘤主要具有滤泡结构；小梁、实性区域、坏死罕见。它们可能具有恶性潜能，因为其恶性转化发生率为35%，而滤泡细胞腺瘤的这一比例为5%。嗜酸性滤泡癌很难与嗜酸性腺瘤区分开来。直径大于4 - 5厘米的肿瘤被认为是恶性的。与腺瘤的主要区别在于侵犯甲状腺周围的包膜或血管。它们可以是高分化、低分化或未分化的。嗜酸性乳头状癌和嗜酸性髓样癌罕见。嗜酸性细胞瘤的临床病程比滤泡细胞肿瘤更具侵袭性。电子显微镜（EM）和抗线粒体抗体免疫组化在鉴别诊断中至关重要。EM在确定嗜酸性细胞瘤的成熟程度方面也可能有用。
