我对甲状腺嗜酸细胞瘤的处理方法。
My approach to oncocytic tumours of the thyroid.
作者信息
Asa S L
机构信息
Department of Pathology, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
出版信息
J Clin Pathol. 2004 Mar;57(3):225-32. doi: 10.1136/jcp.2003.008474.
The traditional approach to oncocytic thyroid lesions classified these as a separate entity, and applied criteria that are somewhat similar to those used for follicular lesions of the thyroid. In general, the guidelines to distinguish hyperplasia from neoplasia, and benign from malignant were crude and unsubstantiated by scientific evidence. In fact, there is no basis to separate oncocytic lesions from other classifications of thyroid pathology. The factors that result in mitochondrial accumulation are largely unrelated to the genetic events that result in proliferation and neoplastic transformation of thyroid follicular epithelial cells. The concept of classifying oncocytic lesions, including follicular variant papillary carcinomas, based on nuclear morphology, immunohistochemical profiles, and molecular markers may pave the way for a better understanding of the biology of oncocytic lesions of the thyroid.
传统上，对甲状腺嗜酸细胞性病变的处理是将其归类为一个独立的实体，并应用一些与甲状腺滤泡性病变所用标准 somewhat similar to those used for follicular lesions of the thyroid。一般来说，区分增生与肿瘤、良性与恶性的指南较为粗略，且缺乏科学证据支持。事实上，将嗜酸细胞性病变与甲状腺病理的其他分类区分开来并无依据。导致线粒体聚集的因素在很大程度上与导致甲状腺滤泡上皮细胞增殖和肿瘤转化的基因事件无关。基于核形态、免疫组化特征和分子标志物对包括滤泡状乳头状癌变体在内的嗜酸细胞性病变进行分类的概念，可能为更好地理解甲状腺嗜酸细胞性病变的生物学特性铺平道路。
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